The expression of periostin in hyperplasic scars and the relations to TGF-beta1 and its receptors / 中华整形外科杂志
Chinese Journal of Plastic Surgery
;
(6): 229-232, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-314247
ABSTRACT
<p><b>OBJECTIVE</b>To probe into periostin's role in the pathological mechanism of hyperplasic scars, by examining the expression of periostin in hyperplasic scar tissues. To investigate the correlations between periostin and TGF-beta1, TGF-beta R I, TGF-beta R II.</p><p><b>METHODS</b>RT-PCR was used to assess the mRNA expression levels of TGF-beta1, TGF-beta R I, TGF-beta R II in three kinds of tissues, which are keloid (K), hypertrophic scar (HS) and normal skin (SK). The protein expression of periostin was measured with Western blotting.</p><p><b>RESULTS</b>The mRNA level of periostin in K was higher than that in SK. The mRNA expression of TGF-beta1 in K was higher than that in HS and SK. The mRNA level of TGF-beta R I in K was higher than that in HS and SK. The significances above all was at P < 0.01. The protein expression level of periostin in HS increased, compared with that in SK (P < 0.05). Periostin was related to TGF-beta1 positively (P <0.01).</p><p><b>CONCLUSIONS</b>The periostin's expression is increased in keloids. Periostin is a cicatrix specific gene. Periostin appears to play an important role in the formation of keloids, which is related to TGF-beta1 closely.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Cell Adhesion Molecules
/
Cicatrix, Hypertrophic
/
Receptors, Transforming Growth Factor beta
/
Transforming Growth Factor beta1
/
Keloid
/
Metabolism
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Plastic Surgery
Year:
2007
Type:
Article
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