Compound huangdai tablet as induction therapy for 193 patients with acute promyelocytic leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 440-442, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-314467
ABSTRACT
<p><b>OBJECTIVE</b>To report the results of curative and adverse effects of compound huangdai tablet (CHDT) as induction therapy for 193 patients with acute promyelocytic leukemia (APL).</p><p><b>METHODS</b>CHDT was administered 1.25 g orally three times a day after meal for three days, then the dosage was gradually increased to 7.5 g/d.</p><p><b>RESULTS</b>One hundred and ninety-three patients achieved complete remission (CR), 78.8% of whom in 30 to 60 days with an average time of 44.3 d. No serious infection, bleeding or DIC occurred during the treatment course. The major adverse effects were gastrointestinal symptoms. There was no change in lanine transaminase, urea, creatinine or electrocardiographic QTc interval in 110 APL patients observed before and after the treatment.</p><p><b>CONCLUSION</b>CHDT therapy is a modality of higher CR rate, good safety and tolerance without bone marrow suppression for APL patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Promyelocytic, Acute
/
Follow-Up Studies
/
Treatment Outcome
/
Plant Preparations
/
Therapeutic Uses
/
Drug Therapy
/
Phytotherapy
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2009
Type:
Article
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