Study of radiation synovectomy using (188)Re-Sulfide in hemophilic arthritis / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 151-152, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-314663
ABSTRACT
<p><b>OBJECTIVE</b>To study the effectiveness of radiation synovectomy with (188)Re-sulfide.</p><p><b>METHODS</b>Twenty rabbit models of joint synovitis were injected intra-articularly with different doses of (188)Re-sulfide from 7.4 to 37.0 MBq. By pathological examination, the effects of (188)Re-sulfide on synovium and cartilage were evaluated. Clinically, 10 joints of 7 cases of hemophilic arthritis with (188)Re-sulfide radiation synovectomy were performed. MRI was taken before and after the synovectomy to evaluate the treatment effects.</p><p><b>RESULTS</b>In rabbit models, when (188)Re-sulfide dose larger than 14.8 MBq, the radiation effect on synovitis was remarkable, including thinning the thickened synovium and reducing the inflammatory cells. When radio-activity dose increased to 37.0 MBq, pathological damage was noted in cartilage. Clinical trial demonstrated that radiation synovectomy by (188)Re-sulfide could reduce the frequencies of intra-articular hemorrhage. MRI showed that edema and villi reduced.</p><p><b>CONCLUSIONS</b>Radiation synovectomy using (188)Re-sulfide is effective on synovitis in hemophilic arthritis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Radiation Effects
/
Radiotherapy
/
Rhenium
/
Sulfides
/
Synovial Membrane
/
Synovitis
/
Ruthenium Radioisotopes
/
Chlorides
/
Follow-Up Studies
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2002
Type:
Article
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