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Cadaver renal transplantation and multivariate analysis for graft survival: a clinical review of 2 016 cases / 中华外科杂志
Chinese Journal of Surgery ; (12): 241-247, 2002.
Article in Chinese | WPRIM | ID: wpr-314873
ABSTRACT
<p><b>OBJECTIVE</b>To review kidney transplantation in the center and analyze the risk factors affecting long-term allograft survival.</p><p><b>METHODS</b>Thirty-two relative variables were analyzed with SAS statistical software. Using Log-rank method, we investigated influence of these variables on short-and long-term survival of grafts. Kaplan-Meier analysis was used to estimate the 1-, 3-, 5-, 10-years graft survival rates and half-life. Proportional hazards regression analysis (Cox model) was used to assess and rank the relative risk of potential variables.</p><p><b>RESULTS</b>The 1-, 3-, 5-, 10-years graft survival rates were 83%, 75%, 66% and 48%. After excluding the patients died with functioning grafts, the 1-, 3-, 5-, 10 years grafts survival rate increased to 89%, 82%, 75% and 69%, respectively. The mean half-life was 8.78 +/- 0.14 and 14.09 +/- 0.20 years, respectively. By Log-rank analysis, factors affecting short- and long-term graft survival were identified as renal function, duration of graft function became normal, cold-ischemia time, presence of acute rejection, delayed graft function, immunosuppressive regimen, complication, infection, anti-rejection therapy. Cox model multivariate analysis showed that there were 18 factors affecting graft survival.</p><p><b>CONCLUSIONS</b>New immunosuppressive agents not only significantly increase short-term graft survival, but also have the better long-term outcome tendency. Making assurance to get high quality donor organ and minimizing the death with graft function may be the most feasible way to prolong graft survival at present.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Transplantation, Homologous / Cadaver / Multivariate Analysis / Kidney Transplantation / Graft Survival / Immunosuppressive Agents Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Transplantation, Homologous / Cadaver / Multivariate Analysis / Kidney Transplantation / Graft Survival / Immunosuppressive Agents Type of study: Etiology study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2002 Type: Article