Role of interferon alpha in the management of severe acute pancreatitis / 中华外科杂志
Chinese Journal of Surgery
;
(12): 146-149, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-314912
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy of IFN-alpha on severe acute pancreatitis (SAP) of IFN-alpha.</p><p><b>METHODS</b>A SAP model was developed in adult male rats by retrograde injection of 5% sodium taurocholate in the pancreatic duct. Serum amylase was measured by the blue-starch method and serum cytokines were determined by ELISA.</p><p><b>RESULTS</b>Compared with to the control group, less pancreatic injury and lower amylase level were observed treat in the rats with IFN-alpha. In contrast, the concentration of IL-10 was higher.</p><p><b>CONCLUSION</b>IFN-alpha has significant curative effect on SAP.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Tumor Necrosis Factor-alpha
/
Interleukin-10
/
Interferon-alpha
/
Rats, Sprague-Dawley
/
Pancreatitis, Acute Necrotizing
/
Therapeutic Uses
/
Disease Models, Animal
/
Drug Therapy
/
Immunologic Factors
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2002
Type:
Article
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