Telomerase activity and regulation in human neuroepithelial tumors / 中华外科杂志
Chinese Journal of Surgery
;
(12): 90-93, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-314928
ABSTRACT
<p><b>OBJECTIVE</b>To investigate telomerase activity and expression of hTR and hTERT in human neuroepithelial tumors for exploring new strategy for clinical diagnosis and treatment.</p><p><b>METHODS</b>Telomerase activity was detected by modified TRAP method and the expression of hTR and hTERT was measured by RT-PCR method in 65 human neuroepithelial tumors, respectively.</p><p><b>RESULTS</b>The positive rates of telomerase and hTERT were 61.54% and 70.77% respectively in human neuroepithelial tumors, and the positive rate and their level of expression were correlated with the degree of malignancy of tumors positively.</p><p><b>CONCLUSIONS</b>Telomerase activity and hTERT are significantly correlated with the degree of malignancyin human neuroepithelial tumors. hTERT may play a key role in the regulation of telomerase activity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gene Expression Regulation, Enzymologic
/
Gene Expression Regulation, Neoplastic
/
Neoplasms, Neuroepithelial
/
Telomerase
/
DNA-Binding Proteins
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2002
Type:
Article
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