Multi-centered, randomized controlled clinical study on Chinese medicine formula particles for hyperlipidaemia associated with highly active antiretroviral therapy / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2443-2447, 2013.
Article
in Zh
| WPRIM
| ID: wpr-315007
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect and safety of Xiaozhi particles, integrated taohong Siwu tang and Erchen tang and Xuezhikang capsule in treating hyperlipidaemia (HLP) associated with highly active antiretroviral therapy (HAART).</p><p><b>METHOD</b>In the multi-centered, randomized controlled clinical study, 180 hyperlipidaemia associated with highly active antiretroviral therapy cases were divided into the treatment group treated by Xiaozhi particles, integrated Taohong Siwu tang and Erchen tang, and the control group treated by Xuezhikang capsule. The treatment course was 12 weeks. The total cholesterol (Tch), triglyceride (TG), low density lipoprotein (LDL) and high-density lipoprotein(HDL) were observed.</p><p><b>RESULT</b>After 12 weeks, compared with Xuezhikang capsule, the change difference of Tch, LDL, HDL in the Chinese traditional medicine formula groups of patients is significant (P < 0.05), the change of the TG has no significant difference. The effect of Tch, LDL in Xuezhikang capsule groups is better than in traditional Chinese medicine formula group,but the effect of HDL in traditional Chinese medicine formula group is better than in Xuezhikang capsule groups.</p><p><b>CONCLUSION</b>Integrated Taohong Siwu tang and Erchen tang, Xiaozhi particles and Xuezhikang capsule can be used to control the hyperlipidaemia associated with highly active antiretroviral therapy as one of the main Chinese native medicine preparation.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
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Triglycerides
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Blood
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Drugs, Chinese Herbal
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Cholesterol
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Antiretroviral Therapy, Highly Active
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Therapeutic Uses
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Drug Therapy
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Hyperlipidemias
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Lipoproteins, HDL
Type of study:
Clinical_trials
Limits:
Adult
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Female
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Humans
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Male
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article