Studies on absorption kinetics characteristics of diterpenoid alkaloids in rats after oral administration of Sini Tang powder / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2384-2388, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-315020
ABSTRACT
The purpose of this study was to investigate the absorption kinetics of aconitine, mesaconitine and hypaconitine in rats after oral administration of Sini Tang powder. With cannulate portal and jugular veins cannulated (double-cannulate), conscious moving rats were orally administered Sini Tang. Then samples of portal and systemic blood were collected at the designated periods of time and analyzed for aconitine, mesaconitine and hypaconitine by HPLC. Apparent absorption coefficient of aconitine, mesaconitine and hypaconitine was caculated respectively. The results indicated that the apparent absorption coefficient of aconitine, mesaconitine and hypaconitine come from Sini Tang were 0. 336, 0. 090, 0. 176, respectively, which had some differences among them. It was also suggested that double-cannulated rat was useful for estimating the absorption kinetics of aconitine, mesaconitine and hypaconitine after orally administered Sini Tang by determining the AUC values for drugs in portal and systemic blood samples. The three alkaloids could all be detected in blood, but the absorption differences were existed among the three alkaloids.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Powders
/
Blood
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Kinetics
/
Administration, Oral
/
Rats, Sprague-Dawley
/
Area Under Curve
/
Diterpenes
/
Absorption
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
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