Effect of extract of Ginkgo biloba on doxorubicin-associated cardiotoxicity in patients with breast cancer / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 68-70, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-315178
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of extract of Ginkgo biloba (Egb761) on doxorubicin-associated cardiotoxicity in patients with breast cancer (BC).</p><p><b>METHODS</b>Sixty BC patients in stage IV were randomly assigned to two groups, the control group was treated with chemotherapy, using 4 cycles of PA protocol alone and the treated group with the same chemotherapy and Egb761. Changes in electrocardiogram (ECG), myocardial enzyme spectrum (MES) and ultrasono-cardiogram (USCG) before and after treatment were observed.</p><p><b>RESULTS</b>After treatment, the incidence of abnormal ECG was lower in the treated group than in the control group (6.7% vs 30.0%); significant differences were found between the two groups in the parameters of MES (P< 0.05); USCG showed significant difference between the two groups in left ventricular diastolic diameter (LVDd), left ventricular systolic diameter (LVDs), ratio of early and late diastolic transmitral peak flow velocity (E/A) and fractional shortening (FS), while there was no significant difference in ejection fraction (EF).</p><p><b>CONCLUSION</b>Egb761 is an ideal drug for preventing and reducing the acute doxorbincin-induced cardiotoxicity; it could also be helpful for alleviating the chronic cardiotoxicity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast Neoplasms
/
Plant Extracts
/
Antineoplastic Combined Chemotherapy Protocols
/
Doxorubicin
/
Chemistry
/
Treatment Outcome
/
Carcinoma, Ductal, Breast
/
Ventricular Dysfunction, Left
/
Ginkgo biloba
/
Therapeutic Uses
Type of study:
Practice guideline
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2008
Type:
Article
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