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Research on relationship between angiotensinogen gene M235T and TCM syndrome type in essential hypertension patients / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 36-38, 2008.
Article in Chinese | WPRIM | ID: wpr-315186
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between angiotensinogen (AGT) gene M235T and TCM syndrome type in essential hypertension (ET) patients.</p><p><b>METHODS</b>The gene mutation frequency of AGT M235T in 168 ET patients and 42 nomotensive (NT) subjects were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.</p><p><b>RESULTS</b>There was a significant difference in AGT M235T gene mutation between patients of Gan-fire exuberant type and those of yin-yang deficiency type (P < 0.01), homozygote type TT appeared with higher frequency. Multivariate regression linear analysis demonstrated that the genotypes of AGT M235T was correlated with the prognosis of ET to a certain degree.</p><p><b>CONCLUSION</b>Gene mutation of AGT M235T may be associated with the genesis and development of ET, and the TCM syndrome type of ET has its own intrinsic molecular biological background.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Syndrome / China / Angiotensinogen / Multivariate Analysis / Diagnosis / Diagnosis, Differential / Genetics / Hypertension / Medicine, Chinese Traditional Type of study: Diagnostic study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Syndrome / China / Angiotensinogen / Multivariate Analysis / Diagnosis / Diagnosis, Differential / Genetics / Hypertension / Medicine, Chinese Traditional Type of study: Diagnostic study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2008 Type: Article