The Dose-response of Intrathecal Ropivacaine Co-administered with Sufentanil for Cesarean Delivery under Combined Spinal-epidural Anesthesia in Patients with Scarred Uterus / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2577-2582, 2015.
Article
in English
| WPRIM
| ID: wpr-315290
ABSTRACT
<p><b>BACKGROUND</b>Spinal anesthesia is considered as a reasonable anesthetic option in lower abdominal and lower limb surgery. This study was to determine the dose-response of intrathecal ropivacaine in patients with scarred uterus undergoing cesarean delivery under combined spinal-epidural anesthesia.</p><p><b>METHODS</b>Seventy-five patients with scarred uterus undergoing elective cesarean delivery under combined spinal-epidural anesthesia were enrolled in this randomized, double-blinded, dose-ranging study. Patients received 6, 8, 10, 12, or 14 mg intrathecal hyperbaric ropivacaine with 5 μg sufentanil. Successful spinal anesthesia was defined as a T4sensory level achieved with no need for epidural supplementation. The 50% effective dose (ED50) and 95% effective dose (ED95) were calculated with a logistic regression model.</p><p><b>RESULTS</b>ED50and ED95of intrathecal hyperbaric ropivacaine for patients with scarred uterus undergoing cesarean delivery under combined spinal-epidural anesthesia (CSEA) were 8.28 mg (95% confidence interval [CI] 2.28-9.83 mg) and 12.24 mg (95% CI 10.53-21.88 mg), respectively.</p><p><b>CONCLUSION</b>When a CSEA technique is to use in patients with scarred uterus for an elective cesarean delivery, the ED50and ED95of intrathecal hyperbaric ropivacaine along with 5 μg sufentanil were 8.28 mg and 12.24 mg, respectively. In addition, this local anesthetic is unsuitable for emergent cesarean delivery, but it has advantages for ambulatory patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Uterus
/
Cesarean Section
/
Cicatrix
/
Sufentanil
/
Therapeutic Uses
/
Dose-Response Relationship, Drug
/
Amides
/
Anesthesia, Epidural
/
Anesthesia, Spinal
Type of study:
Controlled clinical trial
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Chinese Medical Journal
Year:
2015
Type:
Article
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