Determination of plasma protein binding rate of bufalin / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2817-2820, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-315355
ABSTRACT
<p><b>OBJECTIVE</b>To study plasma protein binding rate of bufalin.</p><p><b>METHOD</b>HPLC was employed to determine the concentration of bufalin. Plasma protein binding rate studies were conducted by equilibrium dialysis method. The influence of drug concentration and plasma in different species on plasma protein binding rate were studied.</p><p><b>RESULT</b>There was no significant difference in the plasma protein binding rates at low, middle and high bufalin concentrations in dilution medium. The protein binding rate of bufalin in human plasma was higher than in the rat plasma.</p><p><b>CONCLUSION</b>Bufalin has higher protein binding extent with both rat plasma and human plasma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Bufanolides
/
Blood Proteins
/
Kinetics
/
Chemistry
/
Rats, Sprague-Dawley
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS