Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2799-2802, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-315359
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of tetramethylpyrazine (TMP) on the expression of vascular endothelial growth factor (VEGF) in the synovium of adjuvant-induced arthritis (AIA) in rats.</p><p><b>METHOD</b>AIA rats were treated with different doses of TMP. The effects of treatment were monitored by footpad thickness, contents of tumor necrosis factor-alpha (TNF-alpha) in serum, microvessel density (MVD) and the expression of VEGF protein in the synovium.</p><p><b>RESULT</b>Compared with arthritis model, 100 mg x kg(-1) TMP could remarkably reduce the footpad thickness, contents of TNF-alpha in serum and the expression of VEGF in the synovium.</p><p><b>CONCLUSION</b>TMP can attenuate the degree of chronic inflammation in AIA rats, and its mechanism might be associated with inhibiting the expression of VEGF.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Experimental
/
Pyrazines
/
Gene Expression
/
Rats, Wistar
/
Vascular Endothelial Growth Factor A
/
Therapeutic Uses
/
Disease Models, Animal
/
Drug Therapy
/
Genetics
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2009
Type:
Article
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