Correlation analysis between serum interleukin-6 and central nervous injury in septic patients / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1451-1453, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-315444
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between interleukin-6 (IL-6) production and central nervous injury in septic patients.</p><p><b>METHODS</b>Twenty-two septic patients without central nervous system diseases were examined for serum IL-6 and neuron-specific enolase (NSE) levels, and the serum NSE levels and APACHEII scores were compared between patients with low, moderate, and high serum IL-6 levels. The correlations between NSE, APACHEII and serum IL-6 were analyzed.</p><p><b>RESULTS</b>In patients with low, moderate, and high serum IL-6 levels, the serum levels of NSE were 10.29∓4.05, 16.06∓5.84 and 23.97∓3.28 µg/L, respectively, showing a significant difference between the 3 groups (P<0.001). The APACHEII scores also differed significantly between the 3 groups (14.17∓4.67, 16.40∓4.84, and 24.00∓6.26, respectively, P=0.009). Correlation analysis showed significant positive correlations of IL-6 with NSE (r=0.788, P<0.001) and with APACHEII scores (r=0.733, P<0.001).</p><p><b>CONCLUSION</b>In septic patients, serum IL-6 level is significantly correlated with the severity of sepsis and brain injury, and can be used as a marker to monitor brain injury in septic patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Phosphopyruvate Hydratase
/
Blood
/
Brain Injuries
/
Interleukin-6
/
Sepsis
/
APACHE
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS