Impact of maternal hepatitis B surface antigen carrier status on preterm delivery in southern China / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1369-1372, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-315461
ABSTRACT
<p><b>OBJECTIVE</b>To explore the impact of maternal hepatitis B surface antigen (HBsAg) carrier status on the occurrence of preterm birth.</p><p><b>METHODS</b>We analyzed pregnancy-related complications, outcomes and fetal growth index in 188 HBsAg positive singleton pregnant women during the period of May 2009 to July 2011, with 265 HBsAg-negative women with singleton pregnancies in the same period serving as controls.</p><p><b>RESULTS</b>The HBsAg-positive pregnant women showed a significantly higher incidence of placenta praevia than the control group (2.66% vs 0%, P=0.03), and the incidence of preterm delivery (<37 weeks) was also significantly higher in HBsAg-positive group (12.23% vs 6.04%, P=0.02). The incidences of gestational hypertension, preeclampsia, gestational diabetes mellitus, abnormal glucose tolerance, premature rupture of membranes, cesarean delivery, and postpartum hemorrhage showed no significant differences between the two groups (P>0.05), nor did the fetal birth weight, height, head circumference or Apgar scores at 1, 5, and 10 min (P>0.05). Logistic regression identified HBsAg positivity, abnormal ALT, placenta praevia, and severe preeclampsia as the risk factors for preterm delivery.</p><p><b>CONCLUSION</b>HBsAg carrier status can increase the risk of preterm delivery in pregnancy, but it does not seem to affect the fetal growth.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Complications, Infectious
/
Blood
/
Carrier State
/
Case-Control Studies
/
Risk Factors
/
Premature Birth
/
Hepatitis B Surface Antigens
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2012
Type:
Article
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