Therapeutic effect of zoledronic acid on primary osteoporosis in elderly patients / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1287-1289, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-315482
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of zoledronic acid on bone mineral density (BMD) and bone metabolic markers in elderly patients with primary osteoporosis.</p><p><b>METHODS</b>Forty-eight elderly patients with osteoporosis were randomly assigned to zoledronic acid group (n=23) to receive treatment with 5 mg zoledronic acid once a year and the control group (n=25). In both groups, the patients were given Vitamin D3 and caltrate on a daily basis for a year. The bone mineral density (BMD) and bone metabolic markers were observed after the treatment.</p><p><b>RESULTS</b>Compared with the control group, zoledronic acid group had significantly higher L1-4, neck, Inter and Ward's BMD (P<0.05) with reduced B-NTX (P<0.05). The N-MID and CT showed no significant differences between the two groups (P<0.05).</p><p><b>CONCLUSION</b>Zoledronic acid administration once a year can increase BMD and lower the serum bone turnover metabolism, and can be used in the treatment of primary osteoporosis in elderly patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoporosis
/
Bone Density
/
Treatment Outcome
/
Therapeutic Uses
/
Diphosphonates
/
Drug Therapy
/
Bone Density Conservation Agents
/
Imidazoles
/
Metabolism
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2012
Type:
Article
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