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Pancreatic Endocrine Tumors: A Report on a Patient Treated with Sorafenib
Journal of Korean Medical Science ; : 954-958, 2011.
Article in English | WPRIM | ID: wpr-31549
ABSTRACT
A 31-yr-old man with abdominal pain was diagnosed with a pancreatic endocrine tumor and multiple hepatic metastases. Despite optimal treatment with interferon alpha, a somatostatin analog, local therapy with high-intensity focused ultrasound ablation for multiple hepatic metastases, and multiple lines of chemotherapy with etoposide/cisplatin combination chemotherapy and gemcitabine monotherapy, the tumor progressed. As few chemotherapeutic options were available for him, sorafenib (800 mg/day, daily) was administered as a salvage regimen. Sorafenib was continued despite two episodes of grade 3 skin toxicity; it delayed tumor progression compared to the previous immunotherapy and chemotherapy. Serial computed tomography scans showed that the primary and metastatic tumors were stable. Thirteen months after beginning targeted therapy, and up to the time of this report, the patient is well without disease progression. We suggest that sorafenib is effective against pancreatic endocrine tumors.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreatic Neoplasms / Pyridines / Skin Diseases / Benzenesulfonates / Tomography, X-Ray Computed / Salvage Therapy / Neuroendocrine Tumors / Liver Neoplasms / Antineoplastic Agents Limits: Adult / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pancreatic Neoplasms / Pyridines / Skin Diseases / Benzenesulfonates / Tomography, X-Ray Computed / Salvage Therapy / Neuroendocrine Tumors / Liver Neoplasms / Antineoplastic Agents Limits: Adult / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2011 Type: Article