Some models of experimental hyperglycemia applying to screening and evaluating the therapeutic effect of antidiabetic drugs

ABSTRACT

In this study, we have carried out a verification of 3 hyperglycemic models to confirm their potential application and to determine a suitable dose for each hyperglycemic agent. Results from our verification showed that the following hyperglycemic models can be used in screening and evaluating hypoglycemic action of natural products hyperglycemic action using oral glucoses at 3g/kg. Hyperglycemic action using IM Adrenalin at 0.5 mg/kg. Hyperglycemic action using IV Streptozocin, at 70mg/kg causing human type II diabetes, at 100 m/kg causing human type I diabetes.