Influence of benzoapyrene on learning and memory and content of amino acid neurotransmitters in hippocampus of rats / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 546-548, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-315707
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of benzo[a]pyrene (B[a]P) on capability of learning and memory and the content of amino acid neurotransmitters in hippocampus of rats.</p><p><b>METHODS</b>Thirty-two healthy, male SD rats were randomly divided into 4 groups according to their weights after intubated into ventricles the solvent control group, 2.5, 5.0 and 10.0 mmol/L groups. 10 microl of B[a]P olive oil solutions, of different concentrations 2.5, 5.0 and 10.0 mmol/L, were injected into rats' lateral ventricles, respectively. Rats in the solvent control group were injected into the same volume of olive oil as that in B[a]P group. Rats' capability of learning and memory was tested by Morris water maze. The content of amino acid neurotransmitters in rats' hippocampus were determined by high performance liquid chromatogram with a fluorescence detector.</p><p><b>RESULTS</b>Compared with the controls, the performances of learning and memory of rats decreased significantly in B[a]P treated groups (P<0.01). Levels of glutamate (Glu) were lower significantly in treated groups than that in controls (P<0.01). No significant differences were found in contents of aspartic acid (Asp), glycine (Gly) and aminobutyric acid (GABA) among the four groups.</p><p><b>CONCLUSION</b>B[a]P can damage rats' spatial learning and memory, and which could be related to decreased contents of excitatory amino acids in hippocampus.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Benzo(a)pyrene
/
Rats, Sprague-Dawley
/
Neurotransmitter Agents
/
Maze Learning
/
Toxicity
/
Amino Acids
/
Hippocampus
/
Memory
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2008
Type:
Article
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