Correlation between drinking behavior and polymorphisms of extracellular superoxide dismutase, aldehyde dehydrogenase 2 genes, and oral squamous cell carcinoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 119-124, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-315860
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between drinking behavior and polymorphism combination of extracellular superoxide dismutase (EC-SOD) and aldehyde dehydrogenase 2 (ALDH2) genes and oral squamous cell carcinoma.</p><p><b>METHODS</b>The genetic polymorphisms of EC-SOD and ALDH2 were analyzed by polymorphism-polymerase chain reaction technique in peripheral blood leukocytes of 750 oral squamous cell carcinoma cases and 750 non-cancer controls.</p><p><b>RESULTS</b>The frequencies of EC-SOD (C/G) and ALDH2 variant genotypes were 38.27% and 69.47% in oral squamous cell carcinoma cases and 21.07% and 44.40% in healthy controls, respectively. Statistical tests showed significant difference in the frequencies between the two groups (P < 0.01). The risk of oral squamous cell carcinoma with EC-SOD (C/G) was significantly higher than that of controls (OR = 2.32). Individuals carrying ALDH2 variant genotypes had high risk of oral squamous cell carcinoma (OR = 2.85). Combined analysis of the polymorphisms showed that percentages of EC-SOD (C/G)/ALDH2 variant genotypes in oral squamous cell carcinoma and control groups were 30.67% and 6.80%, respectively (P < 0.01). Individuals carrying EC-SOD (C/G)/ALDH2 variant genotypes had high risk of oral squamous cell carcinoma (OR = 8.13). The drinking rate of the case group was significantly higher than that in the control group (OR = 2.70). Statistical analysis suggested an interaction between drinking and EC-SOD (C/G) and ALDH2 variant genotypes, which increase risk of oral squamous cell carcinoma (OR = 25.00).</p><p><b>CONCLUSION</b>EC-SOD (C/G) and ALDH2 variant genotypes and drinking are the risk factors in oral squamous cell carcinoma, which could carry out a coordinated attack of oral squamous cell carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Superoxide Dismutase
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Polymerase Chain Reaction
/
Risk Factors
/
Drinking
/
Aldehyde Dehydrogenase
/
Genotype
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
/
Male
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2014
Type:
Article
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