Effects of Porphyromonas gingivalis infection on intercellular adhesion molecule-1 expression in rat vascular smooth muscle cells / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 111-114, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-315862
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Porphyromonas gingivalis (P. gingivalis) ATCC 33277 infection on expression of intercellular adhesion molecule-1 (ICAM-1) in rat vascular smooth muscle cells(VSMC).</p><p><b>METHODS</b>An infection model of rat VSMC invaded by P. gingivalis was established in vitro. The mRNA of ICAM-1 was measured through reverse transcription-polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>Compared with the control group, an apparent and statistically significant increase in expression of ICAM-1 mRNA was observed after 8, 16, and 24 h in P. gingivals-infected rat VSMC (P<0.05). The expression reached its peak at 16 h. Statistically significant differences were observed in the 8 h group and in the other two experimental groups (P<0.05).</p><p><b>CONCLUSION</b>Infection of P. gingivals in rat VSMC can cause increased expression of ICAM-1, which may have an important function in the progression of atherosclerosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Cells, Cultured
/
Porphyromonas gingivalis
/
Intercellular Adhesion Molecule-1
/
Myocytes, Smooth Muscle
/
Muscle, Smooth, Vascular
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2014
Type:
Article
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