Expression of the estrogen receptor and type II collagen in the mandibular condylar cartilage of the human embryo / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 526-529, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-315918
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of the estrogen receptor (ER) and type II collagen in the mandibular condylar cartilage of the human embryo.</p><p><b>METHODS</b>The expression and localization of ERalpha, ERbeta, and type II collagen in the mandibular condylar cartilage of the human embryo were examined through hematoxylin-eosin (HE) and immunohistochemistry staining.</p><p><b>RESULTS</b>Type II collagen was primarily localized in the transitional and hypertrophic layers of the condylar cartilage. ERa was mostly expressed in the transitional and hypertrophic cartilaginous layers of the condylar cartilage. ERa was evenly distributed in the cell, whereas ERbeta was localized in the nuclei. No expression of type II collagen and ER was found in the fibrage and the proliferative layer although minimal expression was found in the calcified cartilage.</p><p><b>CONCLUSION</b>The distribution of ER and type II collagen in the mandibular condylar cartilage was consistent. Estrogen can selectively combine with different subtypes of ER that regulate the ability of the condylar cartilage cells to secrete type II collagens.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunohistochemistry
/
Cartilage
/
Receptors, Estrogen
/
Collagen
/
Collagen Type II
/
Estrogen Receptor alpha
/
Embryo, Mammalian
/
Mandibular Condyle
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2013
Type:
Article
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