Study on antitumor activities of huanglian jiedu decoction / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1461-1463, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-316022
ABSTRACT
<p><b>OBJECTIVE</b>To study the antitumor activity of Huanglian Jiedu decoction (HLJDT).</p><p><b>METHOD</b>Antitumor activities were tested in mice with experimental tumor H22 in vivo, and the thymus index, spleen index and tumor inhibitory rate were evaluated. The effects on cancer cells from human were investigated in vitro using serum pharmacological approach. Swille, SPC-A-1, SGC-7901 and MCF-7 cancer cells were incubated in culture media containing serum from mice medicated with HLJDT. The inhibitory effects of HLJDT serum were observed by MTT assay.</p><p><b>RESULT</b>HLJDT showed significant antitumor activities on H22 in mice. All of the HLJDT serum in different dosage groups could highly inhibit the proliferation of 4 cancer cell lines from human.</p><p><b>CONCLUSION</b>The HLJDT can significantly inhibit the tumor H22 in mice in a dose-dependent manner, the drug serum has obvious anticancer effects against Swille, SPC-A-1, SGC-7901 and MCF-7.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Thymus Gland
/
Drugs, Chinese Herbal
/
Chemistry
/
Cell Line, Tumor
/
Cell Proliferation
/
Dose-Response Relationship, Drug
/
Drug Combinations
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article
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