Comparative analysis of measles genome between vaccine strain and wild-type strain in Zhejiang province of China / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 723-726, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-316107
ABSTRACT
<p><b>OBJECTIVE</b>To explore the distinction between wild-type strain MVi/Zhejiang, CHN/7.05/4 and vaccine strain Shanghai-191 at genome level.</p><p><b>METHODS</b>After sequencing of measles wild-stain MVi/Zhejiang. CHN/7.05/4, the distinction between the wild-type strain and the vaccine strain was analysed by MEGA 3.1 software at genome level, and the antigen variation was studied by means of combining the epidemiological data.</p><p><b>RESULTS</b>There were 822 nucleotide differences (5.17%) and 161 amino acid differences between these two strains, including three glycosylation sites variation found. Meanwhile, the antigen ratio between wild-type strain and vaccine strain was found to be 5.66.</p><p><b>CONCLUSION</b>There should be certain differences between the contemporary wild-type strain MVi/Zhejiang, CHN/7.05/4 and vaccine strain Shanghai-191 at genome level, and the protective effects of measles vaccine should be studied further.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Antigenic Variation
/
Measles Vaccine
/
China
/
Epidemiology
/
Classification
/
Genome, Viral
/
Sequence Analysis, RNA
/
Sequence Analysis, Protein
/
Allergy and Immunology
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2009
Type:
Article
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