Expression and significance of integrin alpha5, beta1 and E-CD in patients with non-small cell lung carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 746-749, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-316311
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between the expressions of integrin alpha5 beta1 and E-CD, and clinicopathological characteristics and prognosis of patients with non-small cell lung carcinoma (NSCLC).</p><p><b>METHODS</b>The expression of integrin alpha5 beta1 and E-CD were analyzed in 53 NSCLC and 12 control specimens by immunohistochemical assay.</p><p><b>RESULTS</b>The expression of integrin alpha5 beta1 was significantly higher in NSCLC (58.5%) than that in normal lung tissue (16.7%), and also positively related with pathological characteristics (P = 0.021), lymph node metastasis (P = 0.006), and clinical stage (P = 0.002). The 3-year survival rate in NSCLC group was significantly lower than that in control group (22.3% vs 40.6% , P = 0.041). The positive expression of E-CD in NSCLC and control group was 32.1% and 91.7%, respectively, and negatively correlated with pathological characteristics (P = 0.010) and lymph node metastasis (P = 0.002). The 3-year survival rate in control group was 19.9%, lower than that in NSCLC group (41.2%, P > 0.05), but the difference is not significant.</p><p><b>CONCLUSION</b>The overexpression of integrin alpha5 beta1 may contribute to lymph node metastasis and play an inverse role, while E-CD may be a beneficial prognostic factor in patients with NSCLC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Smoking
/
Cadherins
/
Survival Analysis
/
Carcinoma, Non-Small-Cell Lung
/
Integrin alpha5beta1
/
Lung Neoplasms
/
Lymphatic Metastasis
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2006
Type:
Article
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