Expression of BCL-10 protein and the relationship with API2-MALT1 fusion gene in extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 678-682, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-316328
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of BCL-10 protein and API2-MALT1 fusion gene in MALT lymphoma.</p><p><b>METHODS</b>Specimens from 86 cases of MALT lymphoma were studied by immunohistochemical staining for BCL-10. RT-PCR was used to detect the transcripts of API2-MALT1 fusion gene.</p><p><b>RESULTS</b>In all 10 cases of Hashimoto thyroiditis only cytoplasmic BCL-10 expression in lymphoid cells was observed. In 86 MALT lymphoma cases, 42 cases (48. 8%) exhibited BCL-10 expression in both nucleus and cytoplasm. API2-MALT1 fusion gene was detected in 35 cases (40. 7%) of MALT lymphoma. BCL-10 nuclear expression was correlated with API2-MALT1 fusion gene transcript (r = 0. 374,P = 0. 000).</p><p><b>CONCLUSION</b>BCL-10 nuclear expression is correlated with API2-MALT1 fusion gene expression in MALT lymphoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Oncogene Proteins, Fusion
/
Cell Nucleus
/
Follow-Up Studies
/
Lymphoma, B-Cell, Marginal Zone
/
Reverse Transcriptase Polymerase Chain Reaction
/
Respiratory Mucosa
/
Cytoplasm
/
Adaptor Proteins, Signal Transducing
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2006
Type:
Article
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