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Expression of BCL-10 protein and the relationship with API2-MALT1 fusion gene in extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 678-682, 2006.
Article in Chinese | WPRIM | ID: wpr-316328
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of BCL-10 protein and API2-MALT1 fusion gene in MALT lymphoma.</p><p><b>METHODS</b>Specimens from 86 cases of MALT lymphoma were studied by immunohistochemical staining for BCL-10. RT-PCR was used to detect the transcripts of API2-MALT1 fusion gene.</p><p><b>RESULTS</b>In all 10 cases of Hashimoto thyroiditis only cytoplasmic BCL-10 expression in lymphoid cells was observed. In 86 MALT lymphoma cases, 42 cases (48. 8%) exhibited BCL-10 expression in both nucleus and cytoplasm. API2-MALT1 fusion gene was detected in 35 cases (40. 7%) of MALT lymphoma. BCL-10 nuclear expression was correlated with API2-MALT1 fusion gene transcript (r = 0. 374,P = 0. 000).</p><p><b>CONCLUSION</b>BCL-10 nuclear expression is correlated with API2-MALT1 fusion gene expression in MALT lymphoma.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Immunohistochemistry / Oncogene Proteins, Fusion / Cell Nucleus / Follow-Up Studies / Lymphoma, B-Cell, Marginal Zone / Reverse Transcriptase Polymerase Chain Reaction / Respiratory Mucosa / Cytoplasm / Adaptor Proteins, Signal Transducing Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Immunohistochemistry / Oncogene Proteins, Fusion / Cell Nucleus / Follow-Up Studies / Lymphoma, B-Cell, Marginal Zone / Reverse Transcriptase Polymerase Chain Reaction / Respiratory Mucosa / Cytoplasm / Adaptor Proteins, Signal Transducing Type of study: Observational study / Prognostic study / Risk factors Limits: Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2006 Type: Article