Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: neopterin and interleukin-2 / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 49-52, 2005.
Article
in English
| WPRIM
| ID: wpr-316378
ABSTRACT
<p><b>OBJECTIVE</b>To estimate the impact of autologous transfusion on the status of perioperative immune activation in malignant tumor patients. The Serum Neopterin and Interleukin-2 (IL-2) were measured.</p><p><b>METHODS</b>Sixty patients undergoing elective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups (1) Group A received autologous transfusion. (2) Group H received allogeneic transfusion. The perioperative course (Before induction of anesthesia, after operation and 5 d after operation) of Neopterin and IL-2 was compared.</p><p><b>RESULTS</b>In group A, Serum Neopterin was significantly lower than baseline after operation and IL-2 had no significant changes. In group H, both Serum Neopterin and IL-2 were significantly lower than baseline after operation and 5 d after operation. Compared with group A, Serum Neopterin was significantly lower than baseline after operation and 5 d after operation and IL-2 was significantly lower than baseline 5 d after operation.</p><p><b>CONCLUSION</b>Autologous transfusion decreased the perioperative immune suppression in malignant stomach tumor patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postgastrectomy Syndromes
/
Stomach Neoplasms
/
General Surgery
/
Blood
/
Blood Transfusion, Autologous
/
Interleukin-2
/
Treatment Outcome
/
Neopterin
/
Perioperative Care
/
Allergy and Immunology
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2005
Type:
Article
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