Impact of loop diuretics on blood sodium in patients hospitalized for heart failure / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 582-587, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-316407
ABSTRACT
<p><b>OBJECTIVE</b>To observe the level of blood sodium in patients hospitalized for heart failure with water-sodium retention treated with loop diuretics and risk factors of low blood sodium.</p><p><b>METHODS</b>We selected 1 378 acute decompensated heart failure patients who visited Anzhen Hospital, and they are treated with loop diuretics, 259 patients with weight loses more than 1 kg in one week was enrolled in the final analysis, and divided into 3 groups Group A (weight reduction between 1-3 kg), Group B (weight reduction between 3-5 kg) and Group C (weight reduction over 5 kg). Blood sodium, creatinine and uric acid were compared among groups and risk factors of low blood sodium were analyzed.</p><p><b>RESULTS</b>Blood sodium was similar before and post loop diuretics treatment in Group A, and reduced in group B ((138.28 ± 3.73) mmol/L vs. (139.34 ± 3.66) mmol/L, P < 0.05) and in Group C((137.60 ± 4.07) mmol/L vs. (139.44 ± 4.12) mmol/L, P < 0.05). Forty-six (17.8%) patients developed hyponatremia post loop diuretics treatment. Duration of loop diuretics use was the independent risk infector for hyponatremia (OR = 1.191, 95%CI 1.010-1.385).</p><p><b>CONCLUSIONS</b>Loop diuretics use is safe for treating hospitalized patients for heart failure with water-sodium retention and the risk of developing hyponatremia is low. Duration of loop diuretics use is the independent risk factor of hyponatremia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sodium
/
Blood
/
Sodium, Dietary
/
Acute Disease
/
Risk Factors
/
Creatinine
/
Therapeutic Uses
/
Drug Therapy
/
Sodium Potassium Chloride Symporter Inhibitors
/
Heart Failure
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS