Association between single-nucleotide polymorphisms in the IRAK-4 gene and allergic rhinitis / 中华耳鼻咽喉头颈外科杂志
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
;
(12): 476-480, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-316635
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genetic association pattern between single-nucleotide polymorphisms (SNP) in the interleukin-1 receptor-associated kinase 4 (IRAK-4) gene and allergic rhinitis (AR).</p><p><b>METHODS</b>A population of 379 patients with the diagnosis of AR and 333 healthy controls who lived in Beijing region was recruited. A total of 8 reprehensive marker SNP which were in IRAK-4 gene region were selected according to the Beijing people database from Hapmap website. The individual genotyping was performed by MassARRAY platform. SPSS 13.0 software was used for statistic analysis.</p><p><b>RESULTS</b>Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262 P = 0.0034, OR = 1.7388; rs4251481 P = 0.0023, OR = 2.6593), but not in subjects who were allergic to pollens as well as mix allergens.</p><p><b>CONCLUSION</b>The potential genetic contribution of the IRAK-4 gene to AR demonstrated an allergen-dependant association pattern in Chinese population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Allergens
/
Case-Control Studies
/
Rhinitis, Allergic, Perennial
/
Rhinitis, Allergic, Seasonal
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
/
Allergy and Immunology
/
Interleukin-1 Receptor-Associated Kinases
/
Genetics
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Year:
2012
Type:
Article
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