Role of hypoxia-induced VEGF in blood-spinal cord barrier disruption in chronic spinal cord injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 293-295, 2015.
Article
in English
| WPRIM
| ID: wpr-316798
ABSTRACT
Chronic spinal cord lesions (CSCL) which result in irreversible neurologic deficits remain one of the most devastating clinical problems. Its pathophysiological mechanism has not been fully clarified. As a crucial factor in the outcomes following traumatic spinal cord injury (SCI), the blood-spinal cord barrier (BSCB) disruption is considered as an important pathogenic factor contributing to the neurologic impairment in SCI. Vascular endothelial growth factor (VEGF) is a multirole element in the spinal cord vascular event. On one hand, VEGF administrations can result in rise of BSCB permeability in acute or sub-acute periods and even last for chronic process. On the other hand, VEGF is regarded to be correlated with angiogenesis, neurogenesis and improvement of locomotor ability. Hypoxia inducible factor-1 (HIF-1) is a primary regulator of VEGF during hypoxic conditions. Therefore, hypoxia-mediated up-regulation of VEGF may play multiple roles in the BSCB disruption and react on functional restoration of CSCL. The purpose of this article is to further explore the relationship among HIF-1, hypoxia-mediated VEGF and BSCB dysfunction, and investigate the roles of these elements on CSCL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Spinal Cord
/
Spinal Cord Injuries
/
Chronic Disease
/
Neovascularization, Physiologic
/
Vascular Endothelial Growth Factor A
/
Hypoxia-Inducible Factor 1
/
Neurogenesis
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2015
Type:
Article
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