The therapeutic effect of high-dose esomeprazole on stress ulcer bleeding in trauma patients / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 41-43, 2015.
Article
in English
| WPRIM
| ID: wpr-316855
ABSTRACT
<p><b>PURPOSE</b>To compare the therapeutic effects of different doses of intravenous esomeprazole on treating trauma patients with stress ulcer bleeding.</p><p><b>METHODS</b>A total of 102 trauma patients with stress ulcer bleeding were randomly divided into 2 groups 52 patients were assigned to the high-dose group who received 80 mg intravenous esomeprazole, and then 8 mg/h continuous infusion for 3 days; 50 patients were assigned to the conventional dose group who received 40 mg intravenous esomeprazole sodium once every 12 h for 72 h.</p><p><b>RESULTS</b>Compared with the conventional dose group, the total efficiency of the high-dose group and conventional dose group was 98.08% and 86.00%, respectively (p < 0.05), the hemostatic time was 22.10 h ± 5.18 h and 28.27 h ± 5.96 h, respectively (p < 0.05).</p><p><b>CONCLUSION</b>Both doses of intravenous esomeprazole have good hemostatic effects on stress ulcer bleeding in trauma patients. The high-dose esomeprazole is better for hemostasis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Ulcer
/
Stress, Psychological
/
Wounds and Injuries
/
Peptic Ulcer Hemorrhage
/
Therapeutic Uses
/
Dose-Response Relationship, Drug
/
Drug Therapy
/
Esomeprazole
/
Anti-Ulcer Agents
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2015
Type:
Article
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