Study on antineoplastic effect of earthworm coelomic fluid in vitro / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 409-411, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-316887
ABSTRACT
<p><b>OBJECTIVE</b>To explore the antineoplastic effect in vitro of earthworm coelomic fluid (ECF)on growth inhibition and its mechanism for the tumor cell lines Siha, SW480, Colo205 and PC12.</p><p><b>METHODS</b>MTT colorimetric assay, flow cytometry and morphological analysis were used to test its antitumor activity on tumor cell lines and normal cell line Cos7 in vitro.</p><p><b>RESULTS</b>ECF can inhibit the cell growth of Siha, SW480, Colo205, PC12 and Cos7. But different tumor cell lines showed different sensitivity.</p><p><b>CONCLUSION</b>EFC can significantly inhibit the proliferation of tumor cells in vitro by inducing tumor cells apoptosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oligochaeta
/
Pharmacology
/
Body Fluids
/
Cell Line
/
Chlorocebus aethiops
/
Chemistry
/
PC12 Cells
/
Apoptosis
/
COS Cells
/
Cell Line, Tumor
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2010
Type:
Article
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