Molecular epidemiology investigation of rabies virus nucleoprotein genes in China / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 82-84, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-316959
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the distribution of rabies virus and genetic variation, the genetic characterization and variation of rabies virus strains in China were analyzed.</p><p><b>METHODS</b>The downstream 720 nucleotides of Nucleoprotein (N) gene coding region of the rabies specimens from different areas and host animals were sequenced, and then homology and phylogenesis were analyzed.</p><p><b>RESULTS</b>Nucleotide similarities of 34 N gene sequences were 87.5%-100%, and the deduced amino acid similarities were 93.3%-99.6%. Most of the nucleotide variations were synonymous mutations.</p><p><b>CONCLUSION</b>The 34 rabies specimens all belong to genotype I and are of regional characteristic. The rabies viruses in high-incidence areas in China are of various origins and present the transmission tendency from high-incidence areas to surrounding regions. There may be cross-infection and mutual spread of rabies virus between wildlife and domestic animals as well as native and foreign animals.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Rabies
/
Rabies virus
/
Virology
/
RNA, Viral
/
China
/
Classification
/
Molecular Epidemiology
/
Genetics
/
Nucleoproteins
Type of study:
Screening study
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2010
Type:
Article
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