A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" / 中西医结合学报
Journal of Integrative Medicine
;
(12): 1-4, 2016.
Article
in English
| WPRIM
| ID: wpr-317055
ABSTRACT
Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pichia
/
Therapeutics
/
Recombinant Fusion Proteins
/
Transferrin
/
Genetic Therapy
/
Weight Loss
/
Fibronectins
/
Furin
/
Genetics
/
Obesity
Limits:
Humans
Language:
English
Journal:
Journal of Integrative Medicine
Year:
2016
Type:
Article
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