Protective role of Triphala, an Indian traditional herbal formulation, against the nephrotoxic effects of bromobenzene in Wistar albino rats / 中西医结合学报
Journal of Integrative Medicine
;
(12): 115-121, 2015.
Article
in English
| WPRIM
| ID: wpr-317099
ABSTRACT
<p><b>OBJECTIVE</b>The purpose of the present study was to evaluate the nephroprotective and antioxidant properties of Triphala against bromobenzene-induced nephrotoxicity in female Wistar albino rats.</p><p><b>METHODS</b>Animals were divided into five groups of six rats and treated as follows Group I was a normal control and received no treatment, Group II received only bromobenzene (10 mmol/kg), Groups III and IV received bromobenzene and Triphala (250 and 500 mg/kg, respectively), Group V received Triphala alone (500 mg/kg), and Group VI received bromobenzene and silymarin (100 mg/kg). Antioxidant status and serum kidney functional markers were analyzed.</p><p><b>RESULTS</b>Bromobenzene treatment resulted in significant (P< 0.05) decreases in the activities of antioxidant enzymes such as catalase, superoxide dismutase, glutathione-S-transferase and glutathione peroxidase as well as total reduced glutathione. There was a significant (P< 0.05) increase in lipid peroxidation in kidney tissue homogenates. There were significant (P< 0.05) reductions in the levels of serum total protein and albumin as well as significant (P< 0.05) increases in serum creatinine, urea and uric acid. The oral administration of two different doses (250 and 500 mg/kg) of Triphala in bromobenzene-treated rats normalized the tested parameters. The histopathological examinations of kidney sections of the experimental rats support the biochemical observations.</p><p><b>CONCLUSION</b>Triphala treatment alleviated the nephrotoxic effects of bromobenzene by increasing the activities of antioxidant enzymes and reducing the levels of lipid peroxidation and kidney functional markers.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Silymarin
/
Bromobenzenes
/
Chemistry
/
Treatment Outcome
/
Rats, Wistar
/
Plant Structures
/
Protective Agents
/
Terminalia
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Journal of Integrative Medicine
Year:
2015
Type:
Article
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