Saponins isolated from roots of Chlorophytum borivilianum reduce acute and chronic inflammation and histone deacetylase / 中西医结合学报
Journal of Integrative Medicine
;
(12): 25-33, 2015.
Article
in English
| WPRIM
| ID: wpr-317111
ABSTRACT
<p><b>OBJECTIVE</b>The roots of Chlorophytum borivilanum are used in traditional medicine for the treatment of arthritis and inflammation. The aim of the work was to evaluate the anti-inflammatory activity of isolated saponins from Chlorophytum borivilianum (ISCB).</p><p><b>METHODS</b>The ISCB was screened using the carrageenan-induced paw edema, histamine-induced paw edema, cotton pellet-induced granuloma, and Freund's adjuvant-induced arthritis in rats at orally administered doses of 3, 10, and 30 mg/kg. Effect of ISCB on histone deacetylase (HDAC) level was measured by the HDAC assay at the highest dose (30 mg/kg).</p><p><b>RESULTS</b>The results showed that the ISCB significantly reduced carrageenan-induced inflammation, histamine-induced inflammation, cotton pellet-induced granuloma and Freund's adjuvant-induced arthritis in rats. The ISCB at a dose of 30 mg/kg significantly inhibited HDAC level in rat paw tissue.</p><p><b>CONCLUSION</b>It is concluded that saponins isolated from roots of C. borivilianum possess anti-inflammatory and anti-arthritic properties. ISCB may act by inhibiting histamine, prostaglandin and HDAC. This suggests that ISCBs have potential for therapeutic use in the treatment of inflammation and arthritis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Arthritis, Experimental
/
Saponins
/
Chemistry
/
Rats, Wistar
/
Plant Roots
/
Liliaceae
/
Therapeutic Uses
/
Drug Therapy
/
Toxicity
Limits:
Animals
Language:
English
Journal:
Journal of Integrative Medicine
Year:
2015
Type:
Article
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