Roles of serum and urinary interleukins 13Ralpha2 and other cytokines in pediatric Henoch-Schonlein purpura / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 37-40, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-317326
ABSTRACT
<p><b>OBJECTIVE</b>To study the roles of serum and urinary interleukins (IL)-13Ralpha2, IL-4, IL-6, IL-8 and tumor necrosis factor-alpha(TNF-alpha) in pediatric Henoch-Schonlein purpura (HSP).</p><p><b>METHODS</b>Serum and urinary levels of IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha were examined using ELISA in 52 children with HSP and 45 healthy children. The results were compared between the two groups.</p><p><b>RESULTS</b>Serum levels of IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha in HSP patients with or without renal lesions were higher than those in the control group (p<0.01 or 0.05). Urinary levels of IL-6 and TNF-alpha in HSP patients without renal lesions were higher than those in the control group (p<0.05). Except for urinary levels of IL-6 and TNF-alpha, urinary IL-13Ralpha2 levels in HSP patients with renal lesions (HSPN) were higher than those in the control group (p<0.05).</p><p><b>CONCLUSIONS</b>Cytokines IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha may play roles in the pathogenesis of pediatric HSP/HSPN.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
IgA Vasculitis
/
Blood
/
Cytokines
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Allergy and Immunology
/
Interleukin-13 Receptor alpha2 Subunit
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2009
Type:
Article
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