Effects of mechanical ventilation on plasma IL-6, IL-10 and TNF-alpha in children after cardiopulmonary bypass / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of different models of mechanical ventilation on inflammatory cytokines, IL-6, IL-10 and TNF-alpha, in children after cardiopulmonary bypass (CPB).</p><p><b>METHODS</b>Sixty patients who underwent CPB were randomly divided into group A and group B. After CPB, group A was ventilated with high tidal volume (VT, 10-12 mL/kg) /low positive end-expiratory pressure (PEEP, 3-5 cm H2O), while group B was ventilated with low VT (6-8 mL/kg) /high PEEP (6-9 cm H2O). Plasma levels of IL-6, IL-10 and TNF-alpha were measured before operation, at the end of the operation, and 1 and 6 hrs after operation.</p><p><b>RESULTS</b>Serum levels of IL-6, IL-10 and TNF-alpha in both groups increased significantly at the end of the operation and reached a peak by 1 hr after operation. Group B showed lower serum levels of IL-6, IL-10 and TNF-alpha than group A 1 and 6 hrs after operation.</p><p><b>CONCLUSIONS</b>Mechanical ventilation with low VT /high PEEP may more effectively inhibit the release of inflammatory cytokines than that with high VT /low PEEP in children after CPB.</p>