Establishment of a miniature pig model of mandibular osteoradionecrosis / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 570-574, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-317762
ABSTRACT
<p><b>OBJECTIVE</b>To establish a miniature pig model of mandibular osteoradionecrosis (ORN).</p><p><b>METHODS</b>A single dose of irradiation (IR25 Gy, 28 Gy) was delivered via an electronic linear accelerator to the right mandible of 24 miniature pigs by utilizing three dimensional conformal radiotherapy (3D-CRT). The first molar of the mandible was extracted 2 months after radiation. Mandibular ORN was diagnosed through gross observation, X-ray film, CT, and histopathologic examination.</p><p><b>RESULTS</b>At 3-4 months after radiation, all animals suffered from mandibular ORN after dental extraction. The symptoms of ORN were more severe in the 28 Gy group than in the 25 Gy group.</p><p><b>CONCLUSION</b>A miniature pig model of mandibular ORN can be established through 25 Gy irradiation + dental extraction.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoradionecrosis
/
Particle Accelerators
/
Pathology
/
Radiation Injuries, Experimental
/
Swine
/
Swine, Miniature
/
Tooth Extraction
/
Mandibular Diseases
/
Radiotherapy, Conformal
/
Mandible
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2015
Type:
Article
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