Immunological parameters on prophase of severe hepatitis B / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 370-372, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-318017
ABSTRACT
<p><b>OBJECTIVE</b>To study cellular and humoral immune status on prophase of severe hepatitis B (PSHB).</p><p><b>METHODS</b>56 cases of PSHB patients, 40 cases of chronic hepatitis B (CHB) patients and 20 cases of healthy volunteers were enrolled for detection of CD3+, CD4+, CD8+ and CD3-/CD19+ (B cells) lymphocyte subsets in peripheral blood by flow cytometry. Serum IgG and complement C3 was detected by immunoturbidimetry and analyzed statistically.</p><p><b>RESULTS</b>Compared with CHB group and healthy control group, percentage of lymphocyte subsets CD8+ were significantly lower in PSHB group (P < 0.01 or P < 0.05). While the percentage of lymphocyte subsets CD4+ and ratio of CD4+/CD8+ in PSHB group was obviously higher than those in CHB group (P < 0.+01 or P < 0.05). In addition, There was no significant difference on the percentage of B cell and level of serum IgG between PSHB group and CHB group (P > 0.05, while the level of serum complement C3 in PSHB group were significantly lower than those in CHB group and healthy control group (P < 0.01, P < 0.05).</p><p><b>CONCLUSION</b>PSHB has a certain degree of cellular immune dysfunction, which characterized by cellular immune function hyperfunction and humoral immune suppression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Complement C3
/
T-Lymphocyte Subsets
/
Lymphocyte Count
/
Hepatitis B, Chronic
/
Cell Biology
/
Allergy and Immunology
/
Flow Cytometry
/
Antibodies, Viral
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2013
Type:
Article
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