The progress of research on low-frequency sonophoresis and its applications / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1474-1478, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-318125
ABSTRACT
Low-frequency ultrasound can increase the transdermal delivery of many drugs, including macromolecular drugs. The main mechanism is ultrasonic cavitation. Most researchers pointed out that it could change the form-structure of stratum corneum keratinocytes and, in this way, it can improve the permeability of skin. Low-frequency sonophoresis has been in use for in-vitro experiments and in-vivo animal experiments, and so far, both small-molecules transdermal delivery and macromolecules transdermal delivery have been successfully performed in many experiments. However, there are few reports about the real low-frequency sonophoresis for clinical treatment. A large number of clinical trials are necessary to confirm its safety and practicality. Once its safety is confirmed and the suitable low-frequency sonophoresis devices are developed successfully, Low-frequency Sonophoresis will come to be a safe, effective, controllable, and economic new delivery method.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiation Effects
/
Skin
/
Skin Absorption
/
Administration, Cutaneous
/
Diagnostic Imaging
/
Ultrasonography
/
Metabolism
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2008
Type:
Article
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