Development of nanohydroxyapatite composites as bone grafting materials / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1231-1234, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-318177
ABSTRACT
Hydroxyapatite (HA) is one of ideal materials for bone substitutions due to its intrinsic biocompatibility. However, its relatively poor mechanical properties such as brittleness and low strength have hindered its use in high-load applications. Biotic bones themselves are nanocomposites mainly composed of nanohydroxyapatite (n-HA) and collagen. From biomimetic point of view, nanocomposites of HA could potentially improve both biocompatibility and mechanical properties of bone grafting materials. Recent progress in this field branched into nanocomposites of HA with nonbiodegradable and biodegradable polymers, the latter including collagen, gelatin, chitosan, polylactides as well as polyanhydrides. In this paper, the preparation, biological reactions and mechanical properties of different nanocomposites are reviewed in detail.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Biocompatible Materials
/
Chemistry
/
Durapatite
/
Bone Substitutes
/
Nanocomposites
/
Nanoparticles
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2008
Type:
Article
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