Study on solid dispersion of copovidone-based tanshinone II(A) / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 174-178, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-318697
ABSTRACT
<p><b>OBJECTIVE</b>To apply PVP-S630 in the preparation of tanshinone II(A) (TS II(A)) solid dispersion, in order to improve its dissolution in vitro and reduce the moisture absorption of the solid dispersion.</p><p><b>METHOD</b>Tanshinone II(A) solid dispersion was prepared by spray drying method. Such analytical methods as SEM, DSC, XRD were used to characterize their phases and detect their dissolution, moisture absorption and stability.</p><p><b>RESULT</b>In the solid dispersion prepared with tanshinone II(A) and copovidone with proportion of 110, tanshinone II(A) was scattered on the surface of the carrier in the amorphous form, with a dissolution in vitro up to 100% at 0.5 h and a lower moisture absorption than PVP-K30 solid dispersion prepared with the same proportion. After a three-month accelerated stability test, it showed no significant change in drug dissolution and content.</p><p><b>CONCLUSION</b>The solid dispersion prepared with copovidone as the carrier can significantly improve the dissolution of tanshinone II(A), with a relatively low moisture absorption and high stability, thereby having a good prospect of application.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrrolidines
/
Solubility
/
Time Factors
/
Vinyl Compounds
/
Calorimetry, Differential Scanning
/
Drug Carriers
/
Drugs, Chinese Herbal
/
Pharmaceutical Preparations
/
Water
/
Biological Availability
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
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