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Determination of plasma protein binding rate of arctiin and arctigenin with ultrafiltration / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 432-434, 2013.
Article in Chinese | WPRIM | ID: wpr-318711
ABSTRACT
<p><b>OBJECTIVE</b>To determine the plasma protein binding rate of arctiin and arctigenin.</p><p><b>METHOD</b>The ultrafiltration combined with HPLC was employed to determine the plasma protein binding rate of arctiin and arctigenin as well as rat plasma and healthy human plasma proteins.</p><p><b>RESULT</b>The plasma protein binding rate of arctiin with rat plasma at the concentrations of 64. 29, 32.14, 16.07 mg x L(-1) were (71.2 +/- 2.0)%, (73.4 +/- 0.61)%, (78.2 +/- 1.9)%, respectively; while the plasma protein binding rate of arctiin with healthy human plasma at the above concentrations were (64.8 +/- 3.1)%, (64.5 +/- 2.5)%, (77.5 +/- 1.7)%, respectively. The plasma protein binding rate of arctigenin with rat plasma at the concentrations of 77.42, 38.71, 19.36 mg x L(-1) were (96.7 +/- 0.41)%, (96.8 +/- 1.6)%, (97.3 +/- 0.46)%, respectively; while the plasma protein binding rate of arctigenin with normal human plasma at the above concentrations were (94.7 +/- 3.1)%, (96.8 +/- 1.6)%, (97.9 +/- 1.3)%, respectively.</p><p><b>CONCLUSION</b>The binding rate of arctiin with rat plasma protein was moderate, which is slightly higher than the binding rate of arctiin with healthy human plasma protein. The plasma protein binding rates of arctigenin with both rat plasma and healthy human plasma are very high.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Protein Binding / Binding, Competitive / Blood Proteins / Ultrafiltration / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Lignans / Furans / Glucosides / Metabolism Limits: Animals / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Protein Binding / Binding, Competitive / Blood Proteins / Ultrafiltration / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Lignans / Furans / Glucosides / Metabolism Limits: Animals / Humans / Male Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article