Expression of anti-apoptosis livin gene in acute non-lymphocytic leukemia cells and its clinical significance / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 35-37, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-318721
ABSTRACT
To explore the expression of livin gene in acute non-lymphocytic leukemia (ANLL) cells and its clinical significance, the mRNA level of livin gene in 46 ANLL adult patients were measured by using reverse transcription polymerase chain reaction (RT-PCR). Other 10 healthy adults were selected as normal controls (NC), HL-60 cell line was employed as positive control. The results showed that the mRNA level of livin gene in ANLL patients was significantly higher than that in NC, while it decreased in patients with complete remission (CR). In relapsed patients, the level of livin mRNA increased again. In ANLL patients, the CR rate of patients with livin positive was lower than that of patients with livin negative (p<0.05). It is concluded that overexpression of livin gene may play a synergic role in the pathogenesis of ANLL and associates with CR rate in ANLL. It seems that high expression of livin gene may be used as a marker of poor prognosis in acute non-lymphocytic leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
RNA, Messenger
/
Leukemia, Myeloid, Acute
/
Biomarkers, Tumor
/
Adaptor Proteins, Signal Transducing
/
Inhibitor of Apoptosis Proteins
/
Genetics
/
Metabolism
/
Neoplasm Proteins
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS