Correlation of HLA-alleles with aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1208-1211, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-318756
ABSTRACT
To investigate the correlation between the HLA genes and pathogenesis of aplastic anemia (AA), polymerase chain reaction with specific sequence primers (PCR-SSP) method was used to HLA typing in 82 patients with AA and 400 normal healthy individuals as control. The results showed that A*2301 (1.84%), B*5501 (4.36%) and DRB1*0901 (23.48%) gene frequency in AA patients were significantly higher than those in controls (relative risk RR=5.0253, 3.3645, 2.1269, chi2=4.6634, 6.3120, 9.1511 respectively) (p<0.01). In contrast, DRB1*1301 (1.23%) gene frequency was significantly lower in AA than that in controls, RR=0.2257, chi2=6.6629 (p<0.01). It is concluded that A*2301, B*5501 and DRB1*0901 genes may be considered as the risk markers while DRB1*1301 gene as a protective marker of AA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biomarkers
/
HLA-A Antigens
/
HLA-B Antigens
/
HLA-DR Antigens
/
Alleles
/
Allergy and Immunology
/
HLA-DRB1 Chains
/
Genetics
/
Anemia, Aplastic
Type of study:
Etiology study
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2007
Type:
Article
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