Effect of testosterone propionate on the distribution pattern of calcitonin gene-related peptide in different motoneuron pools / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 739-742, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-318825
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of testosterone propionate (TP) on the distribution pattern of calcitonin gene-related peptide (CGRP) in two types of motoneuron (Mn) pools in rats.</p><p><b>METHOD</b>The double labeling of cholera toxin B subunit coupled with colloidal gold (CB-Au) retrograde identification combining with immunocytochemistry was mainly used to reveal the distribution pattern of CGRP-like immunoreactivity (CGRP-LI) and its changes in the motoneuron pools labeled by CB-Au.</p><p><b>RESULT</b>TP injected intramuscularly 28 days later significantly decreased CGRP expression in Mn pool innervating extensor digitorum longus (EDL, fast-twitch), comparing with corresponding control and castration group respectively (P < 0.001), while no significant effect on Mn pools innervating soleus (SOL, slow-twitch, P > 0.05) was observed.</p><p><b>CONCLUSION</b>EDL-Mn pool is more sensitive to testosterone propionate than SOL-Mn pool in regulating CGRP expression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Calcitonin Gene-Related Peptide
/
Rats, Wistar
/
Muscle Fibers, Slow-Twitch
/
Muscle Fibers, Fast-Twitch
/
Cell Biology
/
Testosterone Propionate
/
Metabolism
/
Motor Neurons
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS