Alteration of beta-amyloid and glutamate transporter in the brain of diabetes rats and the underlying mechanism / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 708-711, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-318831
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alteration of beta-amyloid (Abeta) and glutamate transporter in the brain cortex of diabetes mellitus (DM) rats and the underlying mechanism.</p><p><b>METHODS</b>The rats were randomly divided into control, DM, DM +NaCl, and DM +LiCl groups and diabetes was induced by streptozotocin. The activity of glycogen synthase kinase-3 (GSK-3) and the function of glutamate transporter were measured by 32P-labelling. The amount of Abeta was determined by enzyme-linked immunosorbentassay.</p><p><b>RESULTS</b>In DM group, the level of Abeta40 increased (P < 0.01), but the function of glutamate transporter was impaired (P < 0.05). The activity of GSK-3 was stimulated (P < 0.05). Compared with DM group, the level of Abeta40 was restored (P < 0.01), and the function of glutamate transporter was enhanced (P < 0.05) in LiCl treated group, accompanied by a decreased activity of GSK-3.</p><p><b>CONCLUSION</b>Overproduction of Abeta and impaired glutamate transporter exist in DM rats, and increase of GSK-3 may play a crucial role in this process.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Random Allocation
/
Cerebral Cortex
/
Amyloid beta-Peptides
/
Rats, Sprague-Dawley
/
Lithium Chloride
/
Amino Acid Transport System X-AG
/
Glycogen Synthase Kinase 3
/
Diabetes Mellitus, Experimental
/
Drug Therapy
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Type:
Article
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