Cytochrome P450/epoxyeicosatrienoic acids system and myocardial ischemic-reperfusion injury / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 539-542, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-318868
ABSTRACT
Interests on the effects of cytochrome P450 (CYP450) monooxygenases and epoxyeicosatrienoic acids (EETs) on myocardial ischemic-reperfusion injury has been increased in recent years. The CYP450/EET system may influence the degree of myocardial ischemic-reperfusion injury through "poly-targets", such us oxygen free radical, calcium overload, leukocytes adherence, nitric oxide, ATP-sensitive K+ channels, and mitogen activated protein kinase. The exaggeration or recovery of injury depends on the physical status. Study of factors that affects CYP450/EET, particularly identification of their involvement in cardioprotective signaling and specific roles, will elucidate the mechanisms of myocardial ischemic-reperfusion injury, and find a new way of prevention and treatment. This article will review the relationship between the changes of CYP450/EETs system and myocardial ischemic-reper-
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Myocardial Reperfusion Injury
/
Eicosapentaenoic Acid
/
Cytochrome P-450 Enzyme System
/
Mixed Function Oxygenases
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Type:
Article
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