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Cytochrome P450/epoxyeicosatrienoic acids system and myocardial ischemic-reperfusion injury / 中国医学科学院学报
Article in Chinese | WPRIM | ID: wpr-318868
Responsible library: WPRO
ABSTRACT
Interests on the effects of cytochrome P450 (CYP450) monooxygenases and epoxyeicosatrienoic acids (EETs) on myocardial ischemic-reperfusion injury has been increased in recent years. The CYP450/EET system may influence the degree of myocardial ischemic-reperfusion injury through "poly-targets", such us oxygen free radical, calcium overload, leukocytes adherence, nitric oxide, ATP-sensitive K+ channels, and mitogen activated protein kinase. The exaggeration or recovery of injury depends on the physical status. Study of factors that affects CYP450/EET, particularly identification of their involvement in cardioprotective signaling and specific roles, will elucidate the mechanisms of myocardial ischemic-reperfusion injury, and find a new way of prevention and treatment. This article will review the relationship between the changes of CYP450/EETs system and myocardial ischemic-reper-
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Humans / Myocardial Reperfusion Injury / Eicosapentaenoic Acid / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases / Animals / Metabolism Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Humans / Myocardial Reperfusion Injury / Eicosapentaenoic Acid / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases / Animals / Metabolism Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2005 Type: Article