Your browser doesn't support javascript.
loading
Expression of monocyte chemoattractant protein-1 and lupus nephritis / 中国医学科学院学报
Article in Chinese | WPRIM | ID: wpr-318878
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of monocyte chemoattractant protein-1 (MCP-1) in lupus nephritis (LN).</p><p><b>METHODS</b>Sera MCP-1 levels were measured by enzyme linked immunosorbent assay in 112 patients with systemic lupus erythematosus (SLE), 30 patients with rheumatoid arthritis, 11 non-SLE patients with renal impairment, and 40 healthy volunteers. MCP-1 mRNA expression in peripheral blood mononuclear cells (PBMCs) was also investigated with reverse trancription-polymerase chain reaction semi-quantitative method.</p><p><b>RESULTS</b>The expression of MCP-1 was significantly higher in active LN groups than in all other groups (P < 0.001), and there was a close correlation between MCP-1 expression and the overall SLE disease activity index score (r=0.6245, P < 0.001) and the SLE disease activity index renal score (r=0.6808, P < 0.001). Low expression of MCP-1 was observed in diseased controls and healthy controls. The sera levels of MCP-1 were significantly higher in patients with active diseases than in patients with inactive SLE and controls, but no significant difference were found between the active LN groups and non-renal involvement group (P >0.05).</p><p><b>CONCLUSION</b>The expression of PBMCs MCP-1 mRNA is upregulated in active SLE. Meanwhile, its expression levels are correlated with the activity of LN.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Arthritis, Rheumatoid / Lupus Nephritis / Aged / Female / Humans / Male / RNA, Messenger / Adolescent / Chemokine CCL2 / Adult Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2005 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Arthritis, Rheumatoid / Lupus Nephritis / Aged / Female / Humans / Male / RNA, Messenger / Adolescent / Chemokine CCL2 / Adult Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2005 Type: Article