Expression of monocyte chemoattractant protein-1 and lupus nephritis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 491-495, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-318878
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of monocyte chemoattractant protein-1 (MCP-1) in lupus nephritis (LN).</p><p><b>METHODS</b>Sera MCP-1 levels were measured by enzyme linked immunosorbent assay in 112 patients with systemic lupus erythematosus (SLE), 30 patients with rheumatoid arthritis, 11 non-SLE patients with renal impairment, and 40 healthy volunteers. MCP-1 mRNA expression in peripheral blood mononuclear cells (PBMCs) was also investigated with reverse trancription-polymerase chain reaction semi-quantitative method.</p><p><b>RESULTS</b>The expression of MCP-1 was significantly higher in active LN groups than in all other groups (P < 0.001), and there was a close correlation between MCP-1 expression and the overall SLE disease activity index score (r=0.6245, P < 0.001) and the SLE disease activity index renal score (r=0.6808, P < 0.001). Low expression of MCP-1 was observed in diseased controls and healthy controls. The sera levels of MCP-1 were significantly higher in patients with active diseases than in patients with inactive SLE and controls, but no significant difference were found between the active LN groups and non-renal involvement group (P >0.05).</p><p><b>CONCLUSION</b>The expression of PBMCs MCP-1 mRNA is upregulated in active SLE. Meanwhile, its expression levels are correlated with the activity of LN.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Lupus Nephritis
/
RNA, Messenger
/
Chemokine CCL2
/
Genetics
/
Lupus Erythematosus, Systemic
/
Metabolism
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2005
Type:
Article
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